![]() ![]() Using ex vivo bone marrow cultures, osteoclast-specific staining in the G233V mutant marrow was diminished, whereas osteoblastogenesis was unaffected. With decreased bone resorption, cortical thickness was increased, medullary area decreased, and consequently, the mechanical strength of the femur was significantly increased. Serum measures of bone resorption were significantly decreased in G233V animals. At 6 months of age, G233V mice exhibit a high bone mass phenotype with an approximate doubling of trabecular bone volume in both the tibia and femur. Thus, we examined the skeletal phenotype of mice expressing the G233V variant complex. Recent studies have demonstrated that hematopoetic cells can influence the differentiation of osteogenic cells. The mice have a dramatic increase in splenic megakaryocytes and splenomegaly. We have developed and characterized a mouse model of platelet-type von Willebrand disease (G233V) and have confirmed a platelet phenotype mimicking the human disorder. A limited number of mutations within the glycoprotein Ib-IX complex have been described that permit a structurally altered receptor to interact with soluble von Willebrand factor, and this is the molecular basis of platelet-type von Willebrand disease. The platelet glycoprotein Ib-IX receptor binds surface-bound von Willebrand factor and supports platelet adhesion to damaged vascular surfaces. Her community contributions have also been recognized by the National Organization of Black Elected Legislative Women, YWCA, and Anchorage Chamber of Commerce ATHENA Society.Platelet Dysfunction and a High Bone Mass Phenotype in a Murine Model of Platelet-Type von Willebrand Disease Diane received the Ted Stevens Award from the First Alaskans Institute in 2013 and the Denali Award in 2006 from the Alaska Federation of Natives, the highest honors given to non-Native people by those organizations.Diane received the Distinguished Grantmaker Award, the highest honor awarded by the Council on Foundations, in 2007. In addition, she is a member of the Anchorage Rotary Club. ![]() She is an advisory board member of the Anchorage Schools Foundation, University of Alaska Honors College, Philanthropy Northwest and a member of the National Center for Family Philanthropy Issues Advisory Committee. Diane is a member of the board of the Alaska Community Foundation and a founding board member of United States Artists. Diane was appointed by Governor’s Murkowski, Palin and Parnell to the Alaska Children’s Trust and currently serves as its Chair. ![]() She attended executive management programs at the Wharton School, Stanford University and UC Berkeley. Diane earned a degree in Communications and Women’s Studies from the University of Pennsylvania, graduating summa cum laude. She was previously president and chief executive officer of Alaska’s 28-station public radio network. From 1994-2001, Diane’s consulting company provided management and government relations services to philanthropic and nonprofit organizations and Native corporations and tribes. She began administering the Foundation in 1995. In 2001, Diane Kaplan was named president of the Anchorage, Alaska-based Rasmuson Foundation.
0 Comments
Leave a Reply. |